MODULATION OF THE UNFOLDED PROTEIN RESPONSE IS THE CORE OF MICRORNA-122-INVOLVED SENSITIVITY TO CHEMOTHERAPY IN HEPATOCELLULAR CARCINOMA

Modulation of the Unfolded Protein Response Is the Core of MicroRNA-122-Involved Sensitivity to Chemotherapy in Hepatocellular Carcinoma

The loss of microRNA-122 (miR-122) expression correlates to many characteristic properties of hepatocellular carcinoma (HCC) cells, including clonogenic survival, anchorage-independent growth, migration, invasion, epithelial-mesenchymal transition, and tumorigenesis.However, all of these findings do not sufficiently explain the oncogenic potential

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Aims and Conditions of Catechumenate in the Patristic Tradition and their Possible Application in Modern Church Practice

The article presents main principles of the patristic tradition of catechumenate and their possible application in modern Church practice.Catechetical learning is designed to facilitate full inclusion into the church opi mauvnetic poles modus vivendi, into the life of the new people of God.It necessarily means core change of priorities and acquisit

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The Importance of Integrating Clinical Relevance and Statistical Significance in the Assessment of Quality of Care--Illustrated Using the Swedish Stroke Register.

When profiling hospital performance, quality inicators are commonly evaluated through hospital-specific adjusted means with confidence intervals.When identifying deviations from a norm, large hospitals can have statistically significant results even for clinically irrelevant deviations while important deviations in small hospitals can remain undisc

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